Laboratory of Dusan Hanidziar, MD PhD

Overview

The Hanidziar Lab investigates the immune mechanisms underlying acute respiratory distress syndrome (ARDS) and the effects of hyperoxia on the lungs. Our research has demonstrated that the progression of experimental hyperoxic lung injury is immune cell-dependent. Building on these findings, we are now developing and testing novel therapeutic strategies designed to suppress tissue-destructive immune responses -including those driven by neutrophils and NKT cells - while reinforcing tissue-protective pathways, such as regulatory B cell function, to mitigate lung injury. In collaboration with the Vaccine and Immunotherapy Center, we are currently exploring adoptive B cell therapy as an innovative treatment approach for ARDS.

Collaborators

Mark C. Poznansky, MD PhD
Vaccine and Immunotherapy Center, Massachusetts General Hospital
https://advancingcures.org/vic-management-mark-poznansky/

The Poznansky lab at VIC explores novel mechanisms in immunology that reveal new therapeutic approaches for cancer, infectious and immune mediated diseases

Ruxandra Sîrbulescu, PhD
Vaccine and Immunotherapy Center, Massachusetts General Hospital
https://advancingcures.org/sirbulescu-lab/

The Sîrbulescu Laboratory is interested in developing novel cell-based immunotherapies for the treatment of traumatic nervous system injuries, neurodegenerative diseases, and chronic wounds, and in understanding the mechanisms that allow certain cells to exert their pro-healing functions.

Publications

View publications

Selected Publications

1. Hanidziar D, Dwyer LJ, Ranjeva SL, Csizmadia E, Maheshwari S, Valencia JD, Aspden JW, Farhat N, Otterbein LE, Robson SC, Sîrbulescu RF, Poznansky MC. Protective and Immunomodulatory Functions of Exogenous B Cells in Experimental Hyperoxic Lung Injury. Anesth Analg. 2026 Feb 1;142(2):403-415.
2. Hanidziar D, Nakahori Y, Cahill LA, Gallo D, Keegan JW, Nguyen JP, Otterbein LE, Lederer JA, Robson SC. Characterization of pulmonary immune responses to hyperoxia by high-dimensional mass cytometry analyses. Sci Rep. 2020 Mar 13;10(1):4677.
3. Hanidziar D, Robson SC. Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19. Am J Physiol Lung Cell Mol Physiol. 2021 Jan 1;320(1):L12-L16.

Open Positions

We accept students, residents, fellows and visiting scientists. Please contact Dr. Hanidziar if you are interested in joining the lab.