Laboratory of Michael T. Jaklitsch, MD

Overview

The Jaklitsch Lab focuses on clinical outcomes research utilizing both divisional as well as national databases. Previous research projects focused on various thoracic malignancies, benign thoracic disease and preoperative assessments. In addition, the lab specializes in outcomes of elderly patients and collaborates routinely with the Division of Aging. There are two research fellowships within Dr. Jaklitsch’s lab: the John D. Mitchell Thoracic Oncology Research Fellowship and the John D. Mitchell Surgical Education Fellowship. The former focuses on outcomes in thoracic oncology while the latter contributes to residency curriculum and simulation models. Dr. Jaklitsch has done research at the National Institutes of Health on angiogenesis and gene transfer. His major clinical interest is lung cancer, including the unique needs of elderly cancer patients and the use of minimally invasive techniques such as video-assisted thoracic surgery (VATS).

Publications

Selected Publications

Geospatial analysis as a tool for identification of potential targetable regions for lung cancer screening interventions in Massachusetts

Fatima G Wilder, Miles McAllister, Anupama Singh, Yue Xie, Emanuele Mazzola, Daniel Wiener, Michael T Jaklitsch, Rian M Hasson. J Thorac Dis. 2025 Dec 31;17(12):10708-10718. doi: 10.21037/jtd-2025-1369. Epub 2025 Dec 29.  PubMed

Long-term survival for preoperative versus postoperative treatment of N2 lung cancer: The importance of complete adjuvant therapy for occult N2 disease

Fatemehsadat Pezeshkian, Chandana Adhikarla, Emanuele Mazzola, Hao Li, Carla Vega, Anupama Singh, Fatemeh Hooshmand, Miles McAllister, Rafael Ribeiro Barcelos, Elias Bou Farhat, Abby A White, Matthew M Rochefort, Raphael Bueno, Desiree Steimer, Matthew J Pommerening, Paula A Ugalde Figueroa, Michael T Jaklitsch, Scott J Swanson. JTCVS Open. 2025 Sep 17;28:541-553. doi: 10.1016/j.xjon.2025.09.008. eCollection 2025 Dec.  PubMed

Real-time margin assessment for video-assisted thoracic surgery: A pilot clinical trial

Jayender Jagadeesan, Sarah Lobo, Alan Lucas, Julie Barlow, Ahmed Sadek, Zahra Sarawat Alam, Rajat Mukherjee, Eric J Schmidlin, Michael T Jaklitsch, Lynette Marie Sholl, Raphael Bueno, Scott J Swanson. JTCVS Tech. 2025 Sep 3;34:207-218. doi: 10.1016/j.xjtc.2025.08.015. eCollection 2025 Dec.  PubMed

Association of hypoxemia during one-lung ventilation and postoperative complications: A retrospective cohort study

Andres Zorrilla-Vaca, Daniel A Zapata-Pena, Raphael Bueno, Michael T Jaklitsch, Sergey Karamnov, Matthew B Allen. Anaesth Crit Care Pain Med. 2025 Nov 7:101672. doi: 10.1016/j.accpm.2025.101672. Online ahead of print.  PubMed

Delayed Esophagectomy After Chemoradiation Is Not Associated With Increased Mortality or Recurrence

Daniel P Dolan, Geriam Ruiz-Barreto, Miles McAllister, Fatemehsadat Pezeshkian, Hao Li, Yue Xie, Emanuele Mazzola, Scott J Swanson, Michael T Jaklitsch, Jon O Wee. J Surg Oncol. 2025 Oct;132(5):987-994. doi: 10.1002/jso.70084. Epub 2025 Sep 15.  PubMed

Young lung cancer patients undergoing surgery: Comparison of clinicopathological characteristics and outcomes in patients aged ≤50 years versus >50 years

Rachel T Leo, Evert A Sugarbaker, Miles McAllister, Anupama Singh, Rafael R Barcelos, Ali Basil Ali, Raphael Bueno, Michael T Jaklitsch, Paula Ugalde Figueroa, Scott J Swanson. JTCVS Open. 2024 Dec 20;24:409-422. doi: 10.1016/j.xjon.2024.12.008. eCollection 2025 Apr.  PubMed

Lung Cancer in Patients Under 50: What is the Role of Social Determinants of Health?

Fatima G Wilder, Miles McAllister, Anupama Singh, Yue Xie, Emanuele Mazzola, Michael T Jaklitsch. Clin Lung Cancer. 2025 May;26(3):228-235. doi: 10.1016/j.cllc.2025.02.011. Epub 2025 Feb 20.  PubMed

ASO Author Reflections: Gait Speed as a Brief but Powerful Marker of Frailty in Patients Undergoing Thoracic Surgery

Anupama Singh, Michael T Jaklitsch, Clark DuMontier. Ann Surg Oncol. 2025 Jun;32(6):4193-4194. doi: 10.1245/s10434-025-17209-9. Epub 2025 Mar 19.  PubMed

Feasibility of home step-tracking using wearable devices for older adults undergoing thoracic surgery: A brief report

Anupama Singh, Mary E Cooley, Emanuele Mazzola, Ashley L Deeb, Miles McAllister, Fatemehsadat Pezeshkian, Clark DuMontier, Laura N Frain, Paula Ugalde Figueroa, Desiree Steimer, Michael T Jaklitsch. J Geriatr Oncol. 2025 Apr;16(3):102218. doi: 10.1016/j.jgo.2025.102218. Epub 2025 Mar 4.  PubMed

Gait Speed as a Measure of Frailty and Outcomes After Lung Resection

Anupama Singh, Yue Xie, Emanuele Mazzola, Sue Wang, Miles McAllister, Fatemehsadat Pezeshkian, Lisa Cooper, Laura N Frain, Fatima G Wilder, Desiree Steimer, Michael T Jaklitsch, Clark DuMontier. Ann Surg Oncol. 2025 Jun;32(6):4181-4188. doi: 10.1245/s10434-025-17066-6. Epub 2025 Feb 27.  PubMed

Secondary Esophageal Cancer After Hematopoietic Stem Cell Transplant: An Institutional Case Series

Anupama Singh, Miles McAllister, Ashley L Deeb, Sue X Wang, Kristen Rizza, Vincent T Ho, Harvey Mamon, Peter C Enzinger, Michael T Jaklitsch, Jon O Wee. Ann Thorac Surg Short Rep. 2024 Mar 22;2(3):535-539. doi: 10.1016/j.atssr.2024.02.014. eCollection 2024 Sep.  PubMed

Esophageal Carcinoma Cuniculatum

Lisa A Bevilacqua, Mark Fairweather, Vivian Wang, Mariko S Peterson, Michael T Jaklitsch. Ann Thorac Surg Short Rep. 2024 May 4;2(3):555-558. doi: 10.1016/j.atssr.2024.04.017. eCollection 2024 Sep.  PubMed

The devil is in the details

Desiree Steimer, Michael T Jaklitsch, Scott J Swanson. JTCVS Tech. 2024 Jul 1;27:168. doi: 10.1016/j.xjtc.2024.06.017. eCollection 2024 Oct.  PubMed

Early thoracic surgery consultation and location of therapy impact time to esophagectomy

Ashley L Deeb, Aaron R Dezube, Antonio Lozano, Anupama Singh, Luis E De Leon, Suden Kucukak, Michael T Jaklitsch, Jon O Wee. J Thorac Dis. 2024 Sep 30;16(9):5615-5623. doi: 10.21037/jtd-24-316. Epub 2024 Sep 21.  PubMed

Left Upper Lobectomy vs Trisegmentectomy for Lung Cancer: A Propensity Score-Matched Comparison

Miles A McAllister, Julio Herrera-Zamora, Rafael R Barcelos, Rachel Leo, Evert A Sugarbaker, Anupama Singh, Emanuele Mazzola, Paula A Ugalde Figueroa, Michael T Jaklitsch, Scott J Swanson. Ann Thorac Surg. 2025 Apr;119(4):786-795. doi: 10.1016/j.athoracsur.2024.07.046. Epub 2024 Aug 26.  PubMed