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Gene and Cell Therapy Institute

Advancing transformative gene and cell therapies through collaborative research, clinical trials, and translational innovation at Mass General Brigham.

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Email: mgbGCTI@mgb.org

Overview

The Gene and Cell Therapy Institute (GCTI) at Mass General Brigham is committed to finding targeted and transformative treatments that have the potential to cure diseases or halt their progression. The GCTI is committed to finding targeted and transformative treatments that have the potential to cure diseases or halt their progression.

Our multidisciplinary approach unites more than 500 researchers and clinicians dedicated to advancing gene and cell therapy. We leverage expertise from across the entire Mass General Brigham ecosystem of medical innovation and foster an environment of shared knowledge. Led by renowned cardiac gene therapy pioneer Roger Hajjar, MD, the GCTI accelerates groundbreaking research, conducts clinical trials, and facilitates the development of FDA-approved treatments.

The GCTI is committed to expediting the pace of discovery and development by bridging the gap between academic research and practice industry development. The close relationships between industry, physicians, researchers, and patients enables translation to clinical applications. The GCTI also offers expertise in manufacturing, regulatory, clinical trials, and core laboratory services.

The GCTI's annual research symposium is an exploration of the dynamic research landscape within the Mass General Brigham community, uniting trailblazers who are driving advancements in gene therapies, cell therapies, and gene editing techniques to combat human diseases.

RNA Therapeutics Core
The core accelerates the application of circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs), supporting the translation of RNA-based medicines into clinical practice.

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Visit the RNA Therapeutics Core Site

https://researchcores.partners.org/rnac/about


Gene Editing Core
The core supports precision genome editing, highly sensitive off-target detection, iPSC reprogramming, genome perturbation screening, lentivirus packaging, and translational gene and cell therapy development.

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Visit the Gene Editing Core Site

https://researchcores.partners.org/gec/about


Spark Grant Program

The Spark Grant program aims to fund gene and cell therapy projects led by Mass General Brigham investigators that demonstrate tangible advancements towards clinical applications and commercialization outcomes, including licensing, partnerships, or new company creation.
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Application Process
https://partnershealthcare.sharepoint.com/sites/Vitals/SitePages/GCTI%27s-Spark-Funding-Program.aspx

Gene and Cell Therapy Treatments

Gene and cell therapies are advanced medical treatments designed to stop or slow disease progression. Gene therapy replaces or modifies faulty genes, while cell therapy repairs or replaces damaged cells. Using technologies such as CRISPR, these approaches enable targeted and programmable correction of genetic defects. Mass General Brigham offers a range of FDA-approved gene and cell therapy treatments for certain cancers, hereditary diseases, and blood disorders
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Learn more about Gene and Cell Therapy treatments
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GCTI Team

Gang Ning, PhD
Manager of RNA Therapeutics and Gene Editing Cores
Nandhitha Uma Naresh, PhD
Program Manager
Stanley Chung, PhD
Manufacturing & CMC Program Manager
Susanti Sugianto, MSF
Program Coordinator

How to reach us

Contact the Gene and Cell Therapy Institute to collaborate on research initiatives, explore core services, or learn more about our clinical and translational programs. Our team will connect you with the appropriate scientific or program leadership.
tertiary
email
Email: mgbGCTI@mgb.org
mgbGCTI@mgb.org