Laboratory of Ksenia Kastanenka, PhD
Email: kkastanenka@mgh.harvard.edu
Overview
Alzheimer’s disease has traditionally been viewed as a proteinopathy. However, recent evidence highlights circuit impairments as part of the disease progression. We implement optogenetics to control activity within neuronal circuits and imaging with multiphoton microscopy to monitor circuit dynamics with the aim to dissect the role neural activity plays in onset and development of Alzheimer’s disease.
In an attempt to prevent and/or reverse the disorder, we have partnered with industry leaders to study the effects and mechanisms of action of Alzheimer’s therapeutics. We strongly believe that these translational studies are important for getting effective therapies to patients.
Research Team
Ksenia Kastanenka, PhD
Principal Investigator
Shinya Yokomizo, PhD
Postdoctoral Fellow
Tri Doan, MD, PhD
Postdoctoral Fellow
Md Joynal Abedin, PhD
Postdoctoral Fellow
Lei Bao, MD, PhD
Postdoctoral Fellow
Erika Hicks
Undergraduate Student
Publications
Open Positions
Predoctoral and postdoctoral positions are open in the laboratory. Please apply directly to the Principal Investigator.