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Chiocca Lab
Focused on developing novel genetic therapies for malignant brain tumors, including glioblastomas (GBM). We have developed a novel virus that can kill tumor cells without affecting normal brain cells. We are currently combining this research with novel pharmacological and immunotherapeutic approaches for brain cancer.
Overview
The laboratory is focused on developing novel genetic therapies for malignant brain tumors, including glioblastomas (GBM). A major focus of our research is the engineering of viruses that can kill tumor cells without affecting normal brain cells. We are currently combining this research with novel pharmacological and immunotherapeutic approaches for brain cancer.
Research Projects
- Preclinical evaluation of oncolytic viruses for glioma therapy: This project focuses on the development of a recombinant Herpes virus that specifically kills brain cancer cells and is being prepared for clinical studies.
- Gene, viral, and immuno- therapy of brain tumors: This project studies how to circumvent the host responses that limit the efficacy of novel engineered viruses that target gliomas as well as how to stimulate the antitumor immune response.
- Translational Research on Clinical Trial Specimens From Patients with GBM, Ling, et al Nature 2023, Science Translational Medicine 2025, Meylan, et al, Cell 2026, Wen et al, Neuroncology 2025, Chiocca et al, Neuroncolgy 2022, Translational Medicine 2023 {Marco Himanshu, Raziye, Hiro and Alex).
Featured research
Boston brain cancer trial giving patients the gift of time
Chiocca Lab Members
- Hiroshi Nakashima
- Marco Mineo
- Alexander Ling
- Raziye Piranlioglu
- Himanshu Soni
- Oskar Nowicki
Publications
How to reach us
Contact us with inquiries about ongoing studies, collaboration opportunities, or lab resources:
tertiary
email
Email: mgbneurosurgeryresearchadministration@mgb.org
mgbneurosurgeryresearchadministration@mgb.org