Xin Wang Lab

Overview

Wang lab focuses on identifying therapeutics, biomarkers, and molecular mechanisms of neurodegeneration in neurological disorders, including stroke, traumatic brain injury (TBI), TBI-induced alcohol use, neonatal hypoxic-ischemic brain injury, amyotrophic lateral sclerosis, Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease. We pursue multifaceted therapeutic strategies across multiple models to accelerate recovery from cognitive decline, mood disturbances, sleep disruptions, and physical dysfunction following these disorders. We also collaborate on AI-driven approaches, structure–activity relationship studies, and stem cell–based therapies.

Research Projects

Preclinical evaluation of neuroprotective agents to reduce neurotoxicity in TBI and TBI-induced alcohol use; Multifaceted therapies to enhance cognitive, mood, sleep, and physical recovery after TBI and comorbid alcohol use disorder

Identification of novel biomarkers and neuroprotective compounds for ALS; Discovery of ALS therapeutic targets using molecular biology and AI-driven approaches

Development of new treatments and biochemical biomarkers for neonatal hypoxic-ischemic brain injury

Screening novel therapeutics, identifying biomarkers, and elucidating molecular mechanisms in ischemic stroke and Alzheimer’s, Parkinson’s, and Huntington’s diseases

Active Supports:

National Institutes of Health

The United States Department of Defense

Research Team

Xin Wang, Ph.D.
Associate Professor
Director of Neuroapoptosis Drug Discovery Laboratory

Dr. Wang received her B.S. and M.S. from Liaoning Normal University and the University of Science and Technology of China, respectively, and her Ph.D. from The Hebrew University of Jerusalem. She completed postdoctoral training at the University of Michigan Medical School and then at Brigham and Women’s Hospital, Harvard Medical School. So far, Dr. Wang has published ~170 peer-reviewed papers (23,393 citations; i10-index 118) and has trained ~50 postdoctoral fellows, research staff, clinicians, and research trainees at BWH.

Bharati Sinha, M.D.
Research Scientist

Xiaohui Xing, M.D., Ph.D.
Postdoc Research Fellow

Meimei Zheng, M.D., Ph.D.
Postdoc Research Fellow

Kelin Li
Jointed Ph.D. student

Shikhar Singh
Research Trainee

Jennifer Liu
Research Trainee

Lainey R. Zhang
Research Trainee

Gaurav Sinha, MBBS
Research Observer

Major Lab Alumni

Ana Cook Sirianni, M.S.
Jiying Jiang, M.D., Ph.D.
Rachna S. Pandya, M.D.
Hannah Zhou, M.D., Ph.D.
David Li, Ph.D.
Anastasios Fotinos, M.D.
Yongjin Zhu, Ph.D.
Jian Wang, M.D., Ph.D.
Yanchun Chen, M.D., Ph.D.
Xinmu Zhang, Ph.D.
Yanyang Tu, M.D., Ph.D.
Robert Luo, Ph.D.
Qiaofeng Wu, M.D., Ph.D.
Daphne A Kroessler, B.S.
Wu Chen, Ph.D.
Gopika Das, B.S.
Jennifer Cui, M.D., Ph.D.
Elisha Shan, M.D.
Piergiacomo Cacciamani, M.D. candidate
Zufeng Wang, M.D., Ph.D.
Lillian Wang, M.D., Ph.D.
Bin Peng, M.D., Ph.D.
George Williams, B.S.
Lourie Luo, M.D., Ph.D.
Lucy Xie, M.D., Ph.D.
Aaron Sandhu, B.S.
Yuan Xiong, M.D, Ph.D.
Xiaojing Yuan, M.D., Ph.D.
Eric Fu, B.S.
Mahammed AS Khan, Ph.D.
Tao Li, M.D., Ph.D.
Juan Zhao, Ph.D.

Publications

View publications

Open Positions

Visiting Scholar Position

12–24-month J-1 Visiting Scholar or Postdoctoral Fellow positions available. Preference for candidates with experience in neurological diseases, animal studies, or alcohol‑ or behavior‑related research. Applicants should hold a Ph.D. or M.D./Ph.D. and have external funding for living expenses. Research costs are covered by Dr. Xin Wang’s lab and Brigham and Women’s Hospital, Harvard Medical School.

Research Trainee Position

The Research Trainee Positions in Neuroscience are available.

Application materials should include a current curriculum vitae and a cover letter describing applicants’ background and research interests.

Please send your application materials to: xwang2@bwh.harvard.edu