Orthopaedic Augmentation, Surgical Innovation, and Interactive Systems Lab (OASIIS) Lab

Overview

The Orthopaedic Augmentation, Surgical Innovation, and Interactive Systems Lab (OASIIS) is an interdisciplinary research team working at the intersection of orthopaedic surgery, interactive media, and data science led by surgeons Daniel Tobert, MD, and Christopher Bono, MD, in collaboration with Ryan Lohre, MD, and Kyle Alpaugh, MD. Nathan Miner, PhD, directs the development and research of the lab’s interactive media projects in collaboration with doctoral student Maria Chiu and Northeastern University Professors Casper Harteveld, PhD, and Aarti Sathyanarayana, PhD. OASIIS is dedicated to innovating orthopedic care using advanced analytical technologies such as artificial intelligence, wearable sensors, and interactive media to optimize outcomes assessment.

Research Projects

Dr. Tobert and Alireza Gholipour, PhD, oversee multiple projects using a comprehensive database assembled for the Mass General Brigham orthopaedic registry. The team has harnessed the registry database to develop individual dashboards that allow surgeons to assess and address their own surgical outcomes in real time. The team is also using the database to better define clinical improvement, stratify risk, and inform patient selection.

Dr. Bono, Nathan Miner, PhD, Maria Chiu, Casper Harteveld, PhD, and Aarti Sathyanarayana, PhD, are assessing patient outcomes using interactive media (virtual reality) and machine learning. The team has developed standardized, immersive activities for patients during which their performance is assessed. In this, they are using gaming technology to develop a "game changer" for collecting and analyzing musculoskeletal outcomes data.

Publications

• Miner N, Bono C, Chiu M, Chua T, Coan J, Harteveld C, Myers C, Lohre R. Examining the Disabilities of Arm, Shoulder, and Hand (DASH) Outcome Instrument in Extended Reality: X-DASH. JSES Reviews, Reports, and Techniques. 2026 Feb 6:100685.
• Freeman IA, Chua TL, Coan JM, Osgood A, Bono CM. Specific Patient-Reported Impairments in Normal Endeavors (SPINE): Creating and Preliminarily Validating a Novel Lumbar Radiculopathy Survey. The Spine Journal. 2026 Feb 19.
• Miner N, Gill K, Harteveld C, Bono C, Mehta DH. Media-Dependent Effects in Heart Rate Variability Biofeedback: A Systematic Review of Extended Reality and Screen-Based Training Approaches. Journal of Medical Extended Reality. 2025 May 9;2(1):jmedxr-2024.
• Miner N, Abdollahi A, Myers C, Kosa M, Ghaednia H, Schwab JH, Harteveld C, Troiano GM. Stairway to heaven: a gamified VR journey for breath awareness. In Proceedings of the 2024 CHI Conference on Human Factors in Computing Systems 2024 May 11 (pp. 1-19).
• Miner, N., Myers, C., Shirodkar, V., Wang, Z., Zhang, Q., & Harteveld, C. (2022, October). Magic Mirror on the Wall: Reflecting the Realities of Lower Limb Rehabilitation in Virtual Reality. In 2022 IEEE International Symposium on Mixed and Augmented Reality Adjunct (ISMAR-Adjunct) (pp. 576-581). IEEE.
• Karhade AV, Bernstein DN, Desai V, Bedair HS, O'Donnell EA, Tanaka MJ, Bono CM, Harris MB, Schwab JH, Tobert DG. What Is the Clinical Benefit of Common Orthopaedic Procedures as Assessed by the PROMIS Versus Other Validated Outcomes Tools? Clin Orthop Relat Res. 2022 Sep 1;480(9):1672-1681. doi: 10.1097/CORR.0000000000002241. Epub 2022 May 10. PMID: 35543521; PMCID: PMC9384920.
• Karhade AV, Bono CM, Schwab JH, Tobert DG. Minimum Clinically Important Difference: A Metric That Matters in the Age of Patient-Reported Outcomes. J Bone Joint Surg Am. 2021 Dec 15;103(24):2331-2337. doi: 10.2106/JBJS.21.00773 . PMID: 34665785.
• Koole D, Lans A, Lang JH, de Groot TM, Borkhetaria P, Verlaan JJ, Schwab JH, Tobert DG. Limited health literacy results in lower health-related quality of life in spine patients. Spine J. 2023 Sep 27;S1529-9430(23)03411. PMID: 37774984. https://doi.org/10.1016/j.spinee.2023.09.016. Epub 2023 Sep 27.
• Bernstein DN, Karhade AV, Bono CM, Schwab JH, Harris MB, Tobert DG. Sociodemographic Factors Are Associated with Patient-Reported Outcome Measure Completion in Orthopaedic Surgery: An Analysis of Completion Rates and Determinants Among New Patients. JB JS Open Access. 2022;7(3):e22.00026. PMID: 35935603. PMCID: PMC9355105. https://doi.org/10.2106/JBJS.OA.22.00026. Epub 2022 Aug 04.