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Mucosal Epithelial Biology & Disease - Mou Lab

The Mou Laboratory investigates the fundamental biology of mucosal epithelial tissues and their central role in maintaining barrier integrity, coordinating immune responses, and orchestrating tissue repair. Our research focuses on airway and other mucosal surfaces that are continuously exposed to environmental stressors, pathogens, and inflammatory stimuli. By integrating cell biology, molecular genetics, and system-level approaches, we aim to define how epithelial cells regulate homeostasis and how their dysfunction contributes to acute and chronic disease.
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Overview

The Mou Laboratory studies the mechanisms driving tissue regeneration, remodeling, inflammation, and host–pathogen interactions in epithelial-driven lung diseases. Using primary human airway cells, patient-derived epithelial 3D co-culture models, and multi-omics approaches, we investigate pathways controlling lung development, epithelial stemness, differentiation, barrier integrity, immune responses, and regeneration.

Research Projects

Stem Cells and Human Airway Disease: Generating Functional Patient- and Disease-Specific Epithelium

A major challenge in developing personalized therapies for airway diseases, such as cystic fibrosis (CF), is the limited availability of large numbers of functional airway epithelial cells. Stem cells, with their capacity for long-term self-renewal and multilineage differentiation, offer a promising solution for generating patient-specific cellular resources for therapeutic applications.

Two renewable sources of patient-specific airway stem cells can be established. The first involves isolating and expanding endogenous adult airway stem cells over the long term. The second is derived from patient-specific induced pluripotent stem cells (iPSCs), which can be efficiently differentiated into adult-like airway stem or progenitor cells.

Dr. Mou’s laboratory focuses on generating scalable, renewable populations of airway epithelial stem cells from both primary tissues and iPSCs while maintaining robust differentiation potential. These cells provide essential platforms for disease modeling, precision drug screening, and regenerative approaches aimed at restoring damaged or diseased airway epithelium.

Modeling Molecular Regulators of Human Lung Development and Disease

Neonatal lung abnormalities are a leading cause of early mortality and long-term morbidity in infants. Understanding the cellular and molecular mechanisms that drive normal human lung development is critical for revealing how disruptions in embryonic and fetal programs lead to congenital pulmonary defects.

Our laboratory investigates the pathways that govern specification, lineage determination, and plasticity of human fetal airway and lung progenitor cells. By dissecting these developmental programs, we aim to identify how their dysregulation contributes to congenital and neonatal lung disorders and to uncover potential targets for early therapeutic intervention.

Airway Mucosal Epithelial Biology and Disease Mechanisms

We leverage stem cell–based platforms to study genetically and environmentally influenced airway epithelial diseases, including cystic fibrosis (CF), autosomal dominant hyper-IgE syndrome (AD-HIES; Job syndrome), and SMAD4 gain-of-function (GOF) Myhre syndrome. AD-HIES, caused by loss-of-function mutations in STAT3, is a monogenic disorder with complex multisystem manifestations. Our work has shown that airway epithelial cells carrying AD-HIES–associated STAT3 mutations exhibit altered cellular composition, impaired mucociliary clearance, defective bacterial eradication, and reduced pro-inflammatory responses. These findings demonstrate that epithelial-intrinsic defects directly contribute to chronic lung infections and pneumonia in Job syndrome, emphasizing the need for therapies targeting both epithelial and immune dysfunction. In parallel, we investigate Myhre syndrome, a rare genetic disorder caused by de novo SMAD4 gain-of-function mutations (Ile500). Our research focuses on how dysregulated SMAD4 signaling disrupts epithelial differentiation and tissue homeostasis, with the goal of identifying molecular targets for potential therapeutic interventions in affected patients.

Diversity, Plasticity, and Immune Function of Airway Epithelial Cells in Health and Disease

Human and murine airways comprise a diverse array of epithelial cell types—including basal, ciliated, club, goblet, tuft, ionocyte, neuroendocrine cells, and transitional intermediates—each performing specialized roles in maintaining airway homeostasis. These populations exhibit significant plasticity, dynamically responding to environmental stress, infection, and tissue injury to facilitate repair, adaptation, and coordination of immune defenses. The Mou Laboratory has published a series of studies demonstrating the functional heterogeneity of airway stem cells and their associated lesions, revealing the intricate signaling networks that regulate airway architecture, cell composition, and tissue regeneration. These studies also showed that epithelial cells actively orchestrate neutrophil transepithelial migration, coordinating sophisticated crosstalk among pathogens, epithelial cells, and immune populations, an essential mechanism for effective host defense.

Collectively, this work provides critical insights into how airway epithelial cells maintain homeostasis, regulate regenerative responses, and contribute to disease pathogenesis. These findings enhance our understanding of airway biology and lay the groundwork for developing targeted therapies to treat mucosal inflammatory and infectious diseases, as well as epithelial-related complications in both genetic and acquired lung disorders.

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Publications

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Hongmei Mou Bibliography

Selected Publications
  1. Mou, H, Liu, S et al. Transformation of Wheat with Insecticide gene of Arrowhead Proteinase Inhibitor and Analysis of Transgenic Plants, Chinese Journal of Genetics, 1999; 26 (6): 634-642.
  2. Mou, H., Grazio, H.J., Cook, T.A., Beavo, J.A., and Cote, R.H. cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits. J. Biol. Chem. 1999; 274, 18813-18820.
  3. Mou, H and Cote, R.H. The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit. J Biol Chem. 2001; 276, 27527-27534.
  4. Paglia. M.J., Mou, H and Cote, R.H. Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit. J Biol Chem. 2002; 277, 5017-5023.
  5. Lee. Y., Miron A., Drapkin, R., Nucci, M.R., Medeiros, F., Saleemuddin, A., Garber, J., Birch, C., Mou, H., Gordon, R.W., Cramer, D.W., McKeon, F.D., Crum, C.P. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. Journal of Pathology. J Pathol. 2006; 211(1):26-35.
  6. Longmire, T.A., Ikonomou, L, Hawkins, F., Christodoulou, C., Cao, Y., Jean, J.C., Kwok, L.Y., Mou, H., Rajagopal, J., Shen, S. S., Dowton, A. A., Serra, M., Weiss, D.J., Green, M. D., Snoeck, H.W., Ramirez, M.I., and Kotton, D.N. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012: 10 (4); 398-411.
  7. Mou, H., Zhao, R., Sherwood, R., Ahfeldt, T., Lapey, A., Wain, J., Sicilian, L., Izvolsky, K., Musunuru, K., Cowan, C., and Rajagopal, J. Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs. Cell Stem Cell. 2012; 10 (4): 385-397.
  8. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed luminal epithelial cells into functional stem cells in vivo. Nature. 2013 Nov 14; 503(7475):218-23.
  9. Zhao, R., Fallon, T.R., Saladi, S.V., Pardo-Saganta, A., Villoria, J., Mou, H., Vinarsky, V., Gonzalez-Celeiro, M., Nunna, N., Hariri, L., Camargo, F., Ellisen, L.W., and Rajagopal, J. Yap Is Required for the Maintenance and Regulation of Airway Basal Stem Cell Identity and Epithelial Architecture. Dev Cell. 2014 Jul 28; 30(2):151-65.
  10. Gilpin, S., Ren, X., Okamoto, T., Guyette, J.P., Mou, H., Rajagopal, J. Mathisen, J.D., Vacanti, J.P., and Ott, H.C. Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells (iPSCs) on Decellularized Lung Matrix. Ann Thorac Surg. 2014 Aug 19.
  11. Pardo-Saganta A, Law BM, Tata PR, Villoria J, Saez B, Mou H, Zhao R, Rajagopal J. Injury Induces Direct Lineage Segregation of Functionally Distinct Airway Basal Stem/Progenitor Cell Subpopulations. Cell Stem Cell. 2015 Feb 5; 16(2):184-197.
  12. Dowdall JR, Sadow PM, Hartnick C, Vinarsky V, Mou H, Zhao R, Song PC, Franco RA, Rajagopal J. Identification of distinct layers within the stratified squamous epithelium of the adult human true vocal fold. Laryngoscope. 2015 May 19.
  13. Mou H, Brazauskas K, Rajagopal J. Personalized medicine for cystic fibrosis: establishing human model systems. Pediatr Pulmonol. 2015 Oct; 50 Suppl 40:S14-23. PMID: 26335952.
  14. Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhardt JF, Hsu YC, Rajagopal J. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells., Cell Stem Cell. 2016 Aug 4;19(2):217-31.
  15. Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S and Ellisen LW. ACTL6A is co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation and Poor Prognosis, Cancer Cell. Volume 31, Issue 1, p35–49, 9 January 2017.
  16. Yonker LM*, Mou H*, Chu, KK, Pazos MA, Leung H, Cui D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP, Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. Sci Rep. 2017 Aug 15;7(1):8182. (*: equal contribution).
  17. Yonker LM, Pazos MA, Mou H, Kengyeh K. Chu, Eaton, A, BA, Bonventre, JV, Tearney, GJ, Rajagopal, J, Hurley BP. Neutrophil derived cytosolic PLA2α contributes 1 to bacterial-induced neutrophil transepithelial migration. J Immunol. 2017 Sep 8.
  18. Mou H. Quality before Quantity: Inspecting CFTR. Dev Cell. 2018 03 26; 44(6):655-656. PMID: 29587139. Corresponding author.
  19. Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018 Mar 26;44(6):679-693.
  20. Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 2018 May 3;22(5):653-667.e5.
  21. Levardon H, Yonker LM, Hurley BP, Mou H*. Expansion of Airway Basal Cells and Generation of Polarized Epithelium. Bio Protoc. 2018 Jun 05; 8(11). PMID: 30009215. Corresponding author.
  22. Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018 Aug; 560(7718):319-324. PMID: 30069044.
  23. Ruan J, Hirai H, Yang D, Ma L, Hou X, Jiang H, Wei H, Rajagopalan C, Mou H, Wang G, Zhang J, Li K, Chen YE, Sun F, Xu J. Efficient Gene Editing at Major CFTR Mutation Loci. Mol Ther Nucleic Acids. 2019 Jun 07; 16:73-81. PMID: 30852378; PMCID: PMC6409404.
  24. Feldman MB, Wood M, Lapey A, Mou H. SMAD Signaling Restricts Mucous Cell Differentiation In Human Airway Epithelium. Am J Respir Cell Mol Biol. 2019 Mar 8. Corresponding author.
  25. Hurley BP, Jugo RH, Snow RF, Samuels TL, Yonker LM, Mou H, Johnston N, Rosen R. Pepsin Triggers Neutrophil Migration Across Acid Damaged Lung Epithelium. Sci Rep. 2019 09 24; 9(1):13778. PMID: 31551494.
  26. Long SR, Lanter BB, Pazos MA, Mou H, Barrios J, Su CW, Wang ZQ, Walker WA, Hurley BP, Shi HN. Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace. Sci Rep. 2019 10 31; 9(1):15703. PMID: 31673002.
  27. Feldman MB, Dutko RA, Wood MA, Ward RA, Leung HM, Snow RF, De La Flor DJ, Yonker LM, Reedy JL, Tearney GJ, Mou H, Hurley BP, Vyas JM. Aspergillus fumigatus Cell Wall Promotes Apical Airway Epithelial Recruitment of Human Neutrophils. Infect Immun. 2020 01 22; 88(2). PMID: 31767773; PMCID: PMC6977131.
  28. Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 04 08; 27(4):614-628.e6. PMID: 32130954.
  29. Lu J, Zhu X, Shui JE, Xiong L, Gierahn T, Zhang C, Wood M, Hally S, Love JC, Li H, Crawford BC, Mou H*, Lerou PH*. Rho/SMAD/mTOR triple inhibition enables long-term expansion of human neonatal tracheal aspirate-derived airway basal cell-like cells. Pediatr Res. 2020 May 04. PMID: 32365352. (*: co-corresponding authors).
  30. Mou H. Culture nTAD: A New Avenue for Research in Late-stage Human Lung Development and Perinatal Lung Disease. J Cell Immunol. 2020; 2(5):232 - 236.View Publication. Corresponding author.
  31. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. GWAS Functional Variant rs2076295 Regulates Desmoplakin (DSP) Expression in Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 Jun 18. PMID: 32551799.
  32. Xu J, Livraghi-Butrico A, Hou X, Rajagopalan C, Zhang J, Song J, Jiang H, Wei HG, Wang H, Bouhamdan M, Ruan J, Yang D, Qiu Y, Xie Y, Barrett R, McClellan S, Mou H, Wu Q, Chen X, Rogers TD, Wilkinson KJ, Gilmore RC, Esther CR, Zaman K, Liang X, Sobolic M, Hazlett L, Zhang K, Frizzell RA, Gentzsch M, O'Neal WK, Grubb BR, Chen YE, Boucher RC, Sun F. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021 01 11; 6(1). PMID: 33232302.
  33. Yonker LM, Barrios J, Mou H, Hurley BP. Untapped Potential: Therapeutically Targeting Eicosanoids and Endocannabinoids in the Lung. Clin Pharmacol Ther. 2021 Jul; 110(1):69-81. PMID: 33423293.
  34. Mou H*, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 Apr 20; 35(3):109011. PMID: 33882306. Corresponding author.
  35. Mou H. iPSC-derived Alveolar Type II (iAEC2) Heterogeneity: Revealed by SFTPC Expression. Am J Respir Cell Mol Biol. 2021 Jun 21. PMID: 34153206. Corresponding author.
  36. Hirai H, Liang X, Sun Y, Zhang Y, Zhang J, Chen YE, Mou H, Zhao Y, Xu J. The sodium/glucose cotransporters as potential therapeutic targets for CF lung diseases revealed by human lung organoid swelling assay. Mol Ther Methods Clin Dev. 2022 Mar 10; 24:11-19. PMID: 34977268.
  37. Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H*, Que J*. Contribution of Trp63CreERT2 labeled cells to alveolar regeneration is independent of tuft cells. Elife. 2022 Sep 21;11:e78217. doi: 10.7554/eLife.78217. (*: co-corresponding authors).
  38. Zhang Y, Lin T, Leung HM, Zhang C, Wilson-Mifsud B, Feldman MB, Puel A, Lanternier F, Couderc LJ, Danion F, Catherinot E, Salvator H, Tcherkian C, Givel C, Xu J, Tearney GJ, Vyas JM, Li H, Hurley BP, Mou H*. STAT3 Mutation-Associated Airway Epithelial Defects in Job Syndrome. J Allergy Clin Immunol. 2023 Jan 10. Corresponding author.
  39. Huang G, Liang J, Huang K, Liu X, Taghavifar F, Yao C, Parimon T, Liu N, Dai K, Aziz A, Wang Y, Waldron RT, Mou H, Stripp B, Noble PW, Jiang D. Basal Cell-derived WNT7A Promotes Fibrogenesis at the Fibrotic Niche in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2023 03; 68(3):302-313. PMID: 36318668; PMCID: PMC9989475.
  40. Zhang Y, Black KE, Phung TN, Thundivalappil SR, Lin T, Wang W, Xu J, Zhang C, Hariri LP, Lapey A, Li H, Lerou PH, Ai X, Que J, Park JA, Hurley BP, Mou H*. Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity. Am J Respir Cell Mol Biol. 2023 Feb 8. Corresponding author.
  41. Bankoti K, Wang W, Amonkar GM, Xiong L, Shui JE, Zhao C, Van E, Mwase C, Park JA, Mou H, Fang Y, Que J, Bai Y, Lerou PH, Ai X. Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation. Am J Respir Cell Mol Biol. 2023 Sep 12. PMID: 37699145.
  42. Liang X, Hou X, Bouhamdan M, Sun Y, Song Z, Rajagopalan C, Jiang H, Wei HG, Song J, Yang D, Guo Y, Zhang Y, Mou H, Zhang J, Chen YE, Sun F, Jin JP, Zhang K, Xu J. Sotagliflozin attenuates liver-associated disorders in cystic fibrosis rabbits. JCI Insight. 2024.
  43. Sun Y, Zhang Y, Zhang J, Chen YE, Jin JP, Zhang K, Mou H*, Liang X*, Xu J*. XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions. Cell Biosci. 2024 Co-corresponding author.
  44. Guo F, Zhang L, Yu Y, Gong L, Tao S, Werder RB, Mishra S, Zhou Y, Anamika WJ, Lao T, Inuzuka H, Zhang Y, Pham B, Liu T, Tufenkjian TS, Richmond BW, Wei W, Mou H, Wilson AA, Hu M, Chen W, Zhou X. Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells. EBioMedicine. 2024 Feb 27; 101:105026. PMID: 38417378.
  45. Liu T, Liu S, Rui X, Cao Y, Hecker J, Guo F, Zhang Y, Gong L, Zhou Y, Yu Y, Krishnamoorthyni N, Bates S, Chun S, Boyer N, Xu S, Park JA, Perrella MA, Levy BD, Weiss ST, Mou H, Raby BA, Zhou X. Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signaling and airway inflammation. Eur Respir J. 2024 ; PMID: 38514093.
  46. Liu T, Hecker J, Liu S, Rui X, Boyer N, Wang J, Yu Y, Zhang Y, Mou H, Gomez-Escobar LG, Choi AMK, Raby BA, Weiss ST, Zhou X. The Asthma Risk Gene, GSDMB, Promotes Mitochondrial DNA-induced ISGs Expression. J Respir Biol Transl Med. 2024 Mar 31. PMID: 38737375.
  47. Lin AE, Scimone ER, Thom RP, Balaguru D, Kinane TB, Moschovis PP, Cohen MS, Tan W, Hague CD, Dannheim K, Levitsky LL, Lilly E, DiGiacomo DV, Masse KM, Kadzielski SM, Zar-Kessler CA, Ginns LC, Neumeyer AM, Colvin MK, Elder JS, Learn CP, Mou H, Weagle KM, Buch KA, Butler WE, Alhadid K, Musolino PL, Sultana S, Bandyopadhyay D, Rapalino O, Peacock ZS, Chou EL, Heidary G, Dorfman AT, Morris SA, Bergin JD, Rayment JH, Schimmenti LA, Lindsay ME; MGH Myhre Syndrome Study Group. Emergence of the natural history of Myhre syndrome: 47 patients evaluated in the Massachusetts General Hospital Myhre Syndrome Clinic (2016-2023). Am J Med Genet A. 2024 May 23. PMID: 38779990.
  48. Xu S, Tan S, Romanos P, Reedy JL, Zhang Y, Mansour MK, Vyas JM, Mecsas J, Mou H, Leong JM. Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia. eBioMedicine. 2024 Aug 9.
  49. Kooistra T, Saez B, Roche M, Egea-Zorrilla A, Li D, Anketell D, Nguyen N, Villoria J, Gillis J, Petri E, Vera L, Blasco-Iturri Z, Smith NP, Alladina J, Zhang Y, Vinarsky V, Shivaraju M, Sheng SL, Gonzalez-Celeiro M, Mou H, Waghray A, Lin B, Paksa A, Yanger K, Tata PR, Zhao R, Causton B, Zulueta JJ, Prosper F, Cho JL, Villani AC, Haber A, Rajagopal J, Medoff BD, Pardo-Saganta A. Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages. Cell Rep. 2025 Jun 24.
  50. Di YP and Mou H. Airway Serous Cells: A Comparative Study of Spatial Distribution and Abundance Among Species. J Respir Biol Transl Med. 2024. (corresponding author).
  51. Zhao C, Wang W, Bai Y, Amonkar G, Mou H, Olejnik J, Hume AJ, Mühlberger E, Fang Y, Que J, Fearns R, Ai X, Lerou PH. Activation of STAT3-mediated ciliated cell survival protects against severe infection by respiratory syncytial virus. Journal of Clinical Investigation. 2024 Nov 1;134(21):e183978.
  52. Linday ME, Scimone ER, Lawton J, Richa R, Yonker LM, Di YP, Buch K, Ouyang W, Mo X, Lin AE, and Mou H. Gain-of-Function Variants in SMAD4 Compromise Respiratory Epithelial Function. J Allergy Clin Immunol. 2024. (corresponding author).
  53. Xu S, Zhu T, Mou H, Tan S, Leong JM. Weakened airway epithelial junctions and enhanced neutrophil elastase release contribute to age-dependent bacteremia risk following pneumococcal pneumonia. Aging Cell, 2024.
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How to reach us

Contact us with inquiries about ongoing studies, collaboration opportunities, or lab resources:
tertiary
email
Email: hmou@mgh.harvard.edu
secondary
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Call: 617-724-2890
6177242890
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