Conroy Lab
Email: meconroy@mgh.harvard.edu
Call: 617-726-3850
Overview
Antibodies are crucial in coupling triggers with a downstream immune response. Antibodies recognize both allergen (Fab) and relevant receptors (Fc). But more nuanced structural components drive and diversify their effects. Glycosylation is a key factor in determining the antibody funtion. Glycans on the Fc are critical to downstream responses in part by “selecting” receptor binding targets. We seek to decipher how antibodies and variations in glycans dictate downstream immune responses. We translate these findings to food allergy, eczema/itch, and drug allergy. Antibodies also interact with neurologic system. This neuro-immune interface is largely undefined and has relevance to allergy and anaphylaxis. We utilize an array of techniques and well-defined patient samples to answer these questions. We have strong collaborations with experts in epidemiology, dermatology and neuro-immunology. Our goal is to further elucidate the role of antibodies in human disease and leverage this understanding into novel approaches to disease diagnostics and therapeutics.
Aron Gyorgypal, PhD
Postdoctoral fellow
Research technicians
Tessa Allan
Matthew DePonte