Morizane Lab

Overview

The Morizane Lab develops human kidney models that bridge developmental biology and disease mechanisms. We engineer vascularized kidney organoids and organoid-on-chip systems with precisely controlled flow, shear stress, and matrix environments. By integrating high-content 3D imaging, membrane-tension readouts, and multi-omics, we quantify how mechanical and biochemical signals shape epithelial differentiation, repair programs after injury, and disease-relevant phenotypes. Our approach is designed to be both mechanistic and translational: we build faithful human models, identify causal pathways, and test targeted interventions.

Research Team

Ryuji Morizane, MD, PhD
Associate Professor, Harvard Medical School and Massachusetts General Hopsital

Murat Tekguc, MD, PhD
Postdoctoral fellow, Harvard Medical School and Massachusetts General Hospital

Ran Konoe, MD
Lab technician, Harvard Medical School and Massachusetts General Hospital

Parham Mashouf, MD
Research fellow, Harvard Medical School and Massachusetts General Hospital

Mohamed Ahmed, MD
Research fellow, Harvard Medical School and Massachusetts General Hospital

Honami Honjo, MD
Research fellow, Harvard Medical School and Massachusetts General Hospital

Yuhei Higashi, PhD
Postdoctoral fellow, Harvard Medical School and Massachusetts General Hospital

Publications

View publications

Open Positions

We are interested in candidates motivated to build and apply human kidney organoid and organ-on-chip systems, integrate quantitative imaging and multi-omics, and pursue mechanistic questions with translational relevance. Opportunities may be available for research fellows, and trainees. Please email a CV and a brief statement of interests, including relevant experience.