Pulmonary & Critical Care Medicine Research

Overview

Pulmonary and critical care research at Mass General Brigham advances the understanding and treatment of complex lung diseases through integrated basic, clinical, and translational science. Investigators study conditions such as ARDS, asthma, COPD, pulmonary fibrosis, and lung injury, with a strong focus on immunology, genetics, and disease mechanisms. These programs combine laboratory discovery with clinical trials and epidemiologic research to accelerate the development of new therapies. Together, they drive innovation aimed at improving patient outcomes and transforming care for respiratory and critical illness.

Research focus areas

Core Disease Areas

• Acute respiratory distress syndrome (ARDS)
• Asthma
• Chronic obstructive pulmonary disease (COPD)
• Pulmonary fibrosis / interstitial lung disease
• Lung injury and repair
• Sepsis and critical illness–related lung disease
• Lymphangioleiomyomatosis (LAM)
• Pulmonary hypertension
• Pulmonary vascular disease (PVD)
• Environmental exposure and microbiome

Biological & Mechanistic Research

• Immunology and inflammation
• Lung biology and airway biology
• Genetics and genomics of lung disease
• Host-pathogen interactions

Clinical & Translational Research

• Clinical trials and experimental therapeutics
• Translational (bench-to-bedside) research
• Epidemiology and population health studies
• Outcomes research and health services research

Emerging / Cross-Cutting Areas

• Biomarker discovery
• Precision medicine approaches
• Critical care medicine and ICU-based research