Laboratory of Gary Reynolds, MBBS, PhD
Email: gdreynolds@mgh.harvard.edu
Overview
The Reynolds Lab aims to better understand immune-mediated rheumatic diseases by applying multi-omic data methods and systems immunology. We are focused on (1) identifying immune-stromal interactions that lead to tissue damage and (2) understanding the regulatory processes at the interface between tolerance and persistent inflammation.
There is a crucial need to better understand the mechanisms driving autoimmune diseases and chronic inflammation, especially in conditions with defined triggers where some patients recover and others develop long-term issues. The research addresses gaps in knowledge about immune tolerance failure and the persistence of inflammation. Additionally, the development of fibrosis in immune-mediated diseases leads to significant morbidity, making it essential to explore tissue remodeling and potential therapeutic interventions.
Goals:
To support the development of therapies that can target tissue damage in rheumatic diseases and to understand how self-tolerance is regained in autoimmunity.
Research Projects
- To explore the mechanisms underlying tissue remodeling, damage and fibrosis focusing on conditions such as ANCA-associated vasculitis and Giant Cell Arteritis.
- To investigate immune tolerance, focusing on Lyme arthritis and immune-checkpoint inhibitor induced arthritis.
Research Team
Adrien Antoinette, PhD
Postdoctoral Fellow
Sergio Aguilar Fernandez, PhD
Postdoctoral Fellow
Elias Ruiz Morales
Postdoctoral fellow